Dr. Lara Mahal
2019 Canada Excellence Research Chair
Lara K. Mahal is currently the Canada Excellence Research Chair in Glycomics at the University of Alberta. An expert in glycomics and systems-based approaches to understand glycan regulation and function, she developed lectin microarray technology.
This technology provides a high-throughput method for glycomics that is now widely applied to understand systems from clinical cancer research to host-pathogen interactions.
Lara is also known for her work on microRNA regulation of glycosylation.
As an undergraduate, Professor Mahal studied with Professor Rebecca Braslau, working in the area of pro-chiral carbon radical chemistry. She was a University of California Regents Scholar, and graduated with Highest Honors and a B.A in Chemistry from the University of California, Santa Cruz (UCSC) in 1995.
She obtained her Ph.D. in Chemistry with Professor Carolyn Bertozzi at the University of California, Berkeley in 2000. Her work with Professor Bertozzi established the area of metabolic labeling using bio-orthogonal handles, demonstrating that ketones could be incorporated into cell surface sugars (e.g. sialic acids) through metabolic pathways. For this work she was awarded an American Chemical Society (ACS) Predoctoral Medicinal Chemistry Fellowship.
She then moved to New York City where she was a Jane Coffin Childs Postdoctoral Fellow with Professor James Rothman at Sloan-Kettering Institute (2000-2003) studying the role of synaptotagmin I in calcium-dependent membrane fusion.
In 2003, she started her first independent position as an Assistant Professor in Chemistry at the University of Texas at Austin. Post-tenure in 2009, Professor Mahal moved to NYU, where she helped found the Biomedical Chemistry Institute. In 2016, she was promoted to Full Professor.
As of Fall 2019, she joins the faculty of the University of Alberta as the Canada Excellence Research Chair (CERC) in Glycomics.
Lara has received numerous awards including:
- Arnold and Mabel Beckman Foundation Fellowship (2004),
- NSF Career Award (2007),
- Alfred P. Sloan Foundation Fellowship (2008),
- National Institutes of Health Director’s New Innovator Award (2008)
- Horace Isbell Award for Carbohydrate Chemistry from the American Chemical Society (2017).
It is a glycomic technology developed in the Mahal Lab, provide a rapid analysis of the glycome (1-3). These microarrays utilize immobilized carbohydrate-binding proteins at high spatial density to give specific information on the repertoire of glycans present.
Learn more here.
miRNA can be used to identify glycosylation enzymes and theircorresponding glycans that drive disease states.
Learn more here.